Summary: Glaucoma Fellow, Wilmer Eye Institute, Johns Hopkins School of Medicine
I am interested in the neurobiological processes that lead to retinal ganglion cell death and dysfunction in glaucoma and other optic neuropathies. In particular, I seek to better understand the molecular mechanisms underlying axonal degeneration, dendrite retraction and afferent synapse loss, and cell body death in glaucoma. My goal is to utilize knowledge of these processes to develop targeted neuroprotective strategies to slow or halt RGC death and preserve vision for patients with glaucoma. I am also actively investigating the use of stem cell transplantation to achieve retinal ganglion cell placement, as a potential regenerative treatment for optic nerve disease, with a focus on anatomic incorporation of cell grafts, neurite growth and synapse formation, and electrophysiological retinal circuit integration. My ongoing work employs a well-characterized organotypic retinal explant culture system that lends itself to high resolution time-lapse imaging modalities capable of elucidating cellular and subcellular processes in individual cells over a period of several days.
Northwestern University 2005 BA Biological Sciences
Wilmer Eye Institute, Johns Hopkins University 2018 MD