Most have a favourite colour, I have a favourite cell. Macrophages are tissue-resident immune cells that are the ‘first ones in and last ones out’ in most tissue insults. This crush started in 2018, while investigating a rare immune disorder where chronic EBV infection drove uncontrolled macrophage activation, corrupting our biggest ally into a fatal enemy. I went on to study these cells in other contexts, including pregnancy, where placental macrophages have a plethora of roles essential for fetal health. By the midpoint of my medical studies at Cambridge University, I was committed to dedicating more time to immunology research, which has the potential to transform all fields of medicine. For my PhD, I bring my interests in tissue-resident immunity to triple negative breast cancer (TNBC). TNBC is the most aggressive form of breast cancer and the lack of effective therapies in TNBC is a major unmet clinical need. By combining computational methods with functional disease models, I hope to derive translatable insights to antibody and macrophage-directed responses within tumours, which may yield novel therapeutic strategies in TNBC. Outside of the lab, I am passionate about sports, education outreach and medical education.
University of Cambridge Medicine 2020