Biography

 

Sára Tóth

Sára Tóth

  • Scholar-elect
  • Hungary
  • 2025 PhD Chemistry
  • Corpus Christi College

I grew up in Budapest, Hungary, and I moved to the UK in 2021 to pursue a BSc in Physics at King’s College London, followed by an MPhil in Scientific Computing at the University of Cambridge. During my studies, I was captivated by how complex biological systems can be described through simple yet elegant laws of physics. I am particularly fascinated by the structure of our genome, as it achieves a remarkable level of compaction: approximately 2 metres of DNA are condensed into the micrometre-scale space of the cell nucleus. This mechanism plays an important role in human health, as the spatiotemporal organisation of our genes — regulated by binding proteins in a complex feedback-loop manner — determines whether genes are properly activated or silenced, which can lead to the onset of diseases if disrupted. However, the fascinating question arises: how does a protein find its specific target site on DNA among ~3 billion other base pairs in an environment crowded with millions of other proteins? Throughout my PhD, I intend to investigate these questions using multiscale chromatin computational models and deep learning techniques to gain physiochemical insights into the molecular mechanism of genome organisation.

Previous Education

King's College London (University of London) Physics
University of Cambridge Scientific Computing