Better mental health through memory control

  • April 17, 2019
Better mental health through memory control

Scholar-elect Dhruv Nandamudi will study the role of stress in mental health and how memory control can reduce the impact of triggers.

I am interested in how we can best bolster the efficacy of memory control as a therapeutic intervention.

Dhruv Nandamudi

Dhruv Nandamudi lived most of his early years on the outskirts of Detroit. At eight his family moved to Silicon Valley in California and, despite being very young, the difference in settings was clear to him. Although Silicon Valley was much more multicultural than Detroit, it was also much more competitive. “Silicon Valley was very diverse and also very fast paced and competitive. Everyone was on the edge and stressed out. There was a lot of achievement anxiety,” he says. That culture was reflected at school.

The pressure to achieve good grades ramped up in middle school and Dhruv became aware of the impact of stress on his fellow students’ mental wellbeing. In high school he was a tutor for calculus class and says one girl he was teaching burst into tears because she was struggling to keep up with her peers. “I was struck that she felt that her worth was less because of this. A lot of my classmates felt their worth was linked to how well they did,” he says.

This early awareness has fuelled Dhruv's subsequent studies and interest in how acute stress affects people’s sense of self.

At Cambridge he will do a PhD in Biological Science at the MRC Cognition and Brain Sciences Unit under the supervision of Dr Michael Anderson. There he will investigate the role of stress in mental health and the interplay between memory control and cognitive behavioural strategies to reduce negative environmental triggers.

Dhruv [2019] gives the example of a war veteran whose post-traumatic stress disorder is triggered by watching a film where there is an explosion. That might begin a downward spiral. If that veteran is able to actively suppress that memory or retrieve alternative memories it can make the trigger less potent and negative, he says. He states: “I am interested in how we can best bolster the efficacy of memory control as a therapeutic intervention.”

Early research work

Dhruv had not originally intended to be a researcher. Half of his family are in medicine, including his mother who is an ear, nose and throat surgeon, and two of his uncles. It was no surprise then that he initially wanted to follow in their footsteps and become a doctor.

However, Dhruv got the research bug early. Even while he was at school he was taking part in research studies at Stanford over the summer vacation. He worked in diabetes, cancer and cell biology laboratories. Dhruv was also a national finalist in both the Siemens Competition and Intel International Science and Engineering Fair (ISEF). At Yale Dhruv’s interest in research on mental health and his awareness of the lack of resources for psychology and neuroscience developed gradually. He spent several summers working in clinical mental health settings, for instance, on a psychiatric ward. “I saw the level of care given and felt that a lot of it was really like throwing darts at a board. Doctors would try quite potent drugs and if they didn’t work they would try others to see which one stuck. For some being docile was equated with wellness. I was put off by that,” he says.

The summer after he was a resident counsellor at a hospital in Wisconsin working for a psychological facility whose focus was on cognitive and behavioural therapy.  “I saw the efficacy of that approach in comparison with pharmaceutical attempts to fix complex problems,” says Dhruv.

He became passionate about investigating the causes of mental health issues and finding effective treatments.  

Student stress study

Inspired by his summer work and by a class he was taking in psychology and happiness, Dhruv began working at the Yale Centre for Emotional Intelligence where, through the encouragement of co-director Dr Emma Seppala, he led a large scale study into the effects of student stress on academic performance. Using brain scans, self reporting and measuring cortisol levels, the project investigated how stress might be alleviated through, for instance, mindfulness workshops and leadership training.

The results were presented to the Yale board, including suggestions for simple interventions that could help. Dr Seppala and others, including Gates Cambridge Scholars Dr Molly Crockett and Robert Henderson, encouraged Dhruv to apply to Cambridge and to Gates Cambridge. He did not apply until after graduating because his mother had health problems at the time. In the year between graduating and starting at Cambridge Dhruv has been working in Professor James Gross’ laboratory at Stanford looking at how student stress affects dietary choices.

He hopes his research can help to provide effective treatments for mental health problems and recalls one of his mentors at Yale, Dr Kristi Lockhart, telling him about a girl who had become depressed as a result of complex family problems. She was put on anti-depressants which improved her mood, but did not solve problems, such as abuse and bullying. “It was like putting a bandaid on a bullet wound,” says Dhruv.

 

 

Dhruv Nandamudi

Dhruv Nandamudi

  • Scholar
  • United States
  • 2019 PhD Biological Science at the MRC Cognition and Brain Sciences Unit
  • Downing College

As an undergraduate researcher at the Yale’s Center for Emotional Intelligence and Clinical and Affective Neuroscience Lab, I grew particularly interested in exploring the impact of psychosocial stress on neurological subsystems. In my capacity as director of the Yale Wellness Project, I helped design and conduct a large-scale study aimed at better understanding the role of stress in student life, and mitigating its more deleterious neural effects through the implementation of targeted interventional efforts. At Cambridge’s MRC CBU, my PhD will focus on exploring the neuroscientific relationship between stress and memory control, or, more broadly, motivated forgetting, through a combination of neuroimaging and molecular paradigms. From a clinical standpoint, memory control as such refers to a cognitive process that involves the active suppression of emotionally valent memories in response to environmental triggers, and thereby constitutes a barrier to negative affective states. This bears particular relevance to mental health science for the clinical treatment of mood and anxiety-related disorders. My goal is to better understand the mechanisms guiding the interaction between stress and motivated forgetting in an effort to inform potential treatment methodologies for psychological disorders by enhancing cognitive emotion regulation. I am profoundly honored to be a part of the Gates Cambridge community, and its network of scholars dedicated to bettering the human condition.

Previous Education

Yale University Bachelor of Science in Psychology 2018

Latest News

Public engagement through children’s stories

An award-winning science communicator and tv presenter who honed his communication skills as a Gates Cambridge Scholar is launching a colourful children’s book about gravity. Dr Niraj Lal’s new children’s book, Henry the Flying Emu, is being launched by well-known science journalist broadcaster Robyn Williams AO, host of the ABC Science Show. The book tells the story of an […]

Affecting change for the Māori community

Self-determination lies at the centre of Māori culture. “It’s a way of life,” says Chris Tooley. That idea is also at the heart of his PhD studies at Cambridge and his subsequent work in Parliament and in the community. Chris grew up with a strong sense of being part of the Māori community. He has ancestral […]

On the COVID frontline

Three Gates Cambridge scholars who have been on the medical frontline during the COVID-19 pandemic will be speaking about their experiences at a virtual event next weekend. The event, organised by the Gates Cambridge Alumni Association, will be moderated by Elizabeth Dzeng, Assistant Professor of Medicine at the University of California, San Francisco in the […]

New game tackles Covid conspiracies

A new online game that puts players in the shoes of a purveyor of fake pandemic news is the latest tactic in the UK Government’s efforts to tackle the deluge of coronavirus misinformation that is misleading many and costing lives across the world. Launched to the public today, the Go Viral! game has been developed by the […]