Serotonin and its role in emotional responses

  • April 13, 2021
Serotonin and its role in emotional responses

Jonathan Kanen is lead author on two new papers on how serotonin affects emotional responses.

Our findings on the interaction between the serotonin-depleted state and personal attributes could help inform which individuals are particularly vulnerable to pathological emotional reactions.

Jonathan Kanen et al

Two new studies which shed light on the role of serotonin in emotional responses have been published in leading journals.

Jonathan Kanen [2015] is lead author of both. The first is published in Translational Psychiatry and looked at the influence of the neurotransmitter serotonin on emotional reactions to social conflict.

The study involved volunteers drawing on their memories in order to monitor their emotional reaction to instances of social injustice. It found that reducing the serotonin precursor tryptophan heightened emotional responses and interacted with individuals’ personality traits to produce distinctive emotions. For instance, people who were highly empathic felt a greater sense of guilt when confronted by simulated social situations involving unjust harm. People with psychopathic traits were more likely to show annoyance.

The researchers say their findings about how serotonin levels and personality traits interact have implications for understanding vulnerability to psychopathology and to who might react more to serotonin-modulating treatments.

They say: “We propose that traits in conjunction with the memories our task evoked represent biological priors, which prime individuals to have different emotional reactions in the social world… Our findings on the interaction between the serotonin-depleted state and personal attributes could help inform which individuals are particularly vulnerable to pathological emotional reactions, and who may be more amenable to serotonin-modulating treatments, with implications for psychiatric classification in frameworks such as the Research Domain Criteria.”

Another study led by Jonathan Kanen, who recently completed his PhD in Psychology and has received the Angharad Dodds John Bursary in Mental Health and Neuropsychiatry for 2020-2021, has been published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. It looked at how lowering serotonin might affect how people retain emotional memories relating to threatening or safe situations.

In the study 47 healthy participants were monitored for their reaction to cues that predicted threat or safety. Their serotonin levels were then temporarily lowered and they were tested to see how this affected how they retained the threat and extinction memories. They found that serotonin reduction affected emotional memory and that individuals who were more averse to uncertainty showed an even more marked effect.

The researchers say this shows that serotonin affects emotional responsivity and deepens experts’ understanding of individual vulnerability to psychopathology.

They state: “We have shown for the first time that lowering serotonin [in humans] attenuated the subsequent return of threat responses, conditioned prior to depletion: this has particular clinical relevance…Integrating traits and neurochemical state is relevant for understanding vulnerability in health and may inform transdiagnostic mechanisms of illness to refine psychiatric classification and help direct treatment strategies.”

*Picture credit: Harbin and Wikimedia commons.

Latest News

Weekend of Research 2021 focuses on major global challenges

Thirteen Gates Cambridge Scholars at the annual Gates Cambridge Weekend of Research last weekend in panel discussions on the environment and migration, global justice and democracy and Artificial Intelligence and technology. The subjects covered ranged from legacies of oppression and revolution in Myanmar to a call to radically scale down gold mining. The event was […]

New app aims to help women through the menopause

A new app which helps women to manage the menopause was soft launched last month in collaboration with Mumsnet. Stella is the first product by Vira Health, a company which was co-founded in 2019 by Gates Cambridge Scholar Rebecca Love. Stella offers women relief from the most common symptoms of menopause, including sleep disturbances, hot […]

A global perspective on gender and health

The middle of a global pandemic may not seem the ideal time to move country with a new baby, but Johanna Riha [2011] took up her new role as a research fellow at the United Nations University International Institute for Global Health (UNU-IIGH) in Malaysia during the pandemic and moved to Kuala Lumpur around a […]

Scholars share 2021 Bill Gates Sr. Prize

Two Gates Cambridge Scholars are sharing the 2021 Bill Gates Sr. Prize in recognition of their outstanding research and social leadership. Emma Soneson and Maša Josipović have been selected for the prize which was established by the Gates Cambridge Trustees in June 2012 in recognition of the late Bill Gates Sr.’s role in establishing the […]