Review highlights advances in study of early human development

  • February 23, 2021
Review highlights advances in study of early human development

Veronika Mantziou co-authors a review which highlights how pluripotent stem cells can advance research on early human development.

In this review article, we discuss what we know about the early stages of human development and particularly human gastrulation, a process during which the body plan is established.

Veronika Mantziou

Pluripotent stem cells-based models serve as an excellent tool to study early human development, given that legislation forbids using human embryos to do so, according to a review.

The review, published in the journal Developmental Biology, is co-authored by Gates Cambridge Scholar Veronika Mantziou [2019], who is doing a PhD in Developmental Biology.

The study, Human gastrulation: the embryo and its models, starts from the point of the technical and ethical constraints that make the study of early human development challenging – particularly the period following the first three weeks of development when the fundamental aspects of the body plan are established. The ‘14-day rule’ restricts human embryo research to the first 14 days after fertilisation. As such, there have been no experimental studies beyond this stage – even though human gastrulation, the process during which the body plan is established, takes place in this period.

Over the years, mutagenesis programmes have established the mouse as the reference organism for mammalian development. Nevertheless, the review underlines that, due to the existence of significant species-specific differences, it is clear that studying the mouse is not sufficient to understand what happens in human development.

In the absence of legislation permitting the study of early stage embryo development, the review highlights that pluripotent stem cells (PSCs) are beginning to provide insights. PSCs are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo.

Veronika says: “In this review article, we discuss what we know about the early stages of human development and particularly human gastrulation, a process during which the body plan is established. We look at how it differs from the mouse and what we can learn from human PSC models in order to take research on early human development forward.”

*Picture credit: Professor Alfonso Martinez Arias

Latest News

A global perspective on gender and health

The middle of a global pandemic may not seem the ideal time to move country with a new baby, but Johanna Riha [2011] took up her new role as a research fellow at the United Nations University International Institute for Global Health (UNU-IIGH) in Malaysia during the pandemic and moved to Kuala Lumpur around a […]

Scholars share 2021 Bill Gates Sr. Prize

Two Gates Cambridge Scholars are sharing the 2021 Bill Gates Sr. Prize in recognition of their outstanding research and social leadership. Emma Soneson and Maša Josipović have been selected for the prize which was established by the Gates Cambridge Trustees in June 2012 in recognition of the late Bill Gates Sr.’s role in establishing the […]

The censoring effect of populist anti-media messages

Populist attacks on the press should be viewed as a form of soft censorship which uses journalistic norms regarding objectivity to undermine the media, according to a new study by a Gates Cambridge Scholar. The study, Covering populist media criticism: When journalists’ professional norms turn against them, by Ayala Panievsky, is published in the International […]

An existential detective novel

Amanda Dennis‘ first novel Her Here, published in March, tells the story of Elena, who has lost her mother and is suffering from memory loss caused by the trauma of finding her dead. She is asked by her mother’s friend to search for her daughter Ella, who went missing in Thailand six years earlier, through […]